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Multivariate Time Series Analysis of Physiological and Clinical Data

When Nov 13, 2012
from 12:00 PM to 01:00 PM
Where 6th Floor Amphitheater, Guillermo Arbona Building
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Patricia Ordoñez-Rozo, PhD
Assistant Professor, Department of Computer Science
College of Natural Sciences
University of Puerto Rico Río Piedras Campus

 

Abstract

The complexity and volume of collected medical data is greater now than at any point in the history of medicine. Providers are expected to examine large volumes of data and identify correlations between parameters based on their own clinical experience to detect significant medical events. The information overload that providers face may hinder the diagnostic process.   Existing visualizations to assist the provider in analyzing information consist mainly of tables or plots of values for a particular parameter over time. Multivariate Time Series Amalgams (MTSAs) provide an integrated, multivariate approach to represent clinical and physiological data. The hybrid representation automates the personalization of baselines and threshold values based on a patient’s medical history, while also incorporating traditional baselines and thresholds. MTSA visualizations capture the rate of change of provider-selected parameters and the relationships among them.

The second half of my research consists of developing automated techniques for discovering correlations among parameters over time to assist providers in making a diagnosis. The underlying premise of my research is that the complexity of a highly integrated system such as a human being is better captured by examining patterns as multivariate temporal abstractions as opposed to conjunctions of univariate ones -- the more common approach for multivariate time series analysis and in medicine. The objective of such an approach is to assist in the identification of latent patterns within the data associated with specific medical conditions or events.

Thus, in addition to the MTSA visualizations, I will present two novel multivariate time series representations, Stacked Bags-of-Patterns and Multivariate Bag-of-Patterns, which have been effective at classifying medical data, robotic sensor data, and motion capture data.  These representations are more compact than the raw multivariate time series and would facilitate the retrieval of patients from large medical databases based on physiological similarity and ideally on the presence of similar medically significant events or conditions.

Sponsored by the Departments of Biochemistry, Physiology, Pharmacology and Toxicology &  the RCMI Center for Information Technology and Telecommunications (CentIT2) and the Biomedical Informatics Key Activity of the Puerto Rico Clinical and Translational Research Consortium, with the collaboration of the Department of Computer Sciences, College of Natural Sciences, University of Puerto Rico Río Piedras Campus.

Moving Beyond the Mean: The Role of Variation in Determining Phenotype

Fall 2012 Lecture Series
When Nov 07, 2012
from 11:00 AM to 12:00 PM
Where UPR Comprehensive Cancer Center (UPRCCC)
Contact Phone 787-772-8300
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John Quackenbush, Ph.D.
Dana-Farber Cancer Institute

See the live transmission at:
UPR Comprehensive Cancer Center (UPRCCC) Amphitheater
*a light lunch will be served after the seminar



Next Generation Sequencing Training Seminar

Live Videocast from the Caribbean Genomics Center at UPR-Mayagüez
When Oct 25, 2012 10:00 AM to
Oct 26, 2012 04:00 PM
Where Amphitheater – 6th floor of main building, UPR-Medical Sciences Campus
Contact Name
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REVISED SCHEDULE

25 October 2012
Dept. of Biochemistry Library- Rm A641, 6th floor of main building UPR-Medical Sciences Campus
9:30 am Introducing Caribbean Genome Center – Taras K Oleksyk
10:00am-12:00 Current Perspectives in Genomics Research – Meredith Yeager


26 October 2012
Amphitheater – 6th floor of main building, UPR-Medical Sciences Campus
1:00 pm Sequence Data Analysis For Ion Torrent Data –Joseph Boland, NCI
2:00 pm Ion Torrent Sequencing In Non-Human Models Organisms –Michael Cullen, NCI
3:00 pm Life Technologies for the Biomedical Sciences –Andy Felton, Life Technologies
4:00 pm Question and Answer session –all participants CaribbeanGenome Center at the University of Puerto Rico at Mayaguez

Conference on “Humanized Mouse Model for Research”

When Oct 23, 2012
from 11:00 AM to 01:00 PM
Where UCC- Multipurpose Uses Room, 1st Floor Basic Science Bldg.
Contact Name
Contact Phone 787-798-3001, Ext. 2079
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J. Víctor García-Martínez, Ph.D.
Professor of Medicine, Microbiology and Immunology University of North Carolina Center for AIDS Research Division of Infectious Diseases University of North Carolina, Chapel Hill

 

Persons interested in meeting with the speaker that day
from 1:00 to 3:00 pm please contact:
Zahíraliz Reyes Bou at (787-798-3001, Ext. 2079)
Ivonne Amill at (787-798-3001, Ext 2093)
Irves Rivera at (787-798-3001, Ext 2094)
Confirm your attendance - Lunch will be provided

 

Download flyer & agenda

SPSS: A Hands-On Workshop

Introduction to Database Management and Basic Descriptive Statistics
When Sep 17, 2012
from 01:00 PM to 04:00 PM
Where Room 473-A, Computer Center, 4th Floor UPR-MSC
Contact Name
Contact Phone 787-759-0306 Ext. 234
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Instructors:

  • Linnette Rodriguez, PhD, MS
    Department of Biostatistics and Epidemiology, GSPH, UPR-MSC
  • Raul Ramon, MS
    Data Analyst and PRCTRC DBE Coordinator at Universidad Central del Caribe

 

For reservation please contact Katya Giovannetti

Striatal Glutamate Hyperfunction in Parkinson’s Disease

TRANSLATIONAL RESEARCH SEMINAR SERIES/ NEUROLOGY GRAND ROUND
When Aug 17, 2012
from 11:00 AM to 12:30 PM
Where 6th Floor Amphitheater, Medical Sciences Campus
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Speaker:

Stella Pappa, MD
Emory University School of Medicine

The Role of an Independent Contract Research Organization (WESTAT) In Clinical Research

When Jun 14, 2012
from 12:00 PM to 01:00 PM
Where 1st Floor MSC Main Building, Amphitheater School of Dental Medicine
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SPEAKER:
Laura Freimanis, MD, PhD
Westat, Rockville, MD

 

Partially supported by: National Institutes of Health: HiREC S21MD001830, CRECD Grant Number R25RR017589 from NCRR/R25MD007607 from NIMHD and PRCTRC 8U54MD007587-03.

A Proteomics Workshop

Ponce School of Medicine-Moffitt Cancer Center Partnership
When Jun 01, 2012
from 09:00 AM to 01:00 PM
Where PSM&HS Academic Building First Floor, Room 101
Contact Name
Contact Phone 787.840.2575 x2191
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"Ethical Considerations in Human Biobanking"
Gwen Quinn, PhD

"Proteomics for Cancer Research and Personalized Medicine"
John Koomen, PhD

"Using Proteomics to Personalize Melanoma Therapy"
Keiran Smalley, PhD

 

Lunch with Speakers to follow Presentations

*Registration begins at 8:30 am

Capacity Building for HIV-HPV Clinical Trials Recruitment among Minority Underserved Populations of Hispanic Origin

Save the Date
When May 25, 2012
from 08:00 AM to 04:30 PM
Where Marriott Courtyard Isla Verde Beach Resort
Contact Name Ms. Leticia Roman Torres
Contact Phone (787) 772-8300 ext. 1208
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This workshop is designed to give up-to-date information to health care providers about clinical trials and of the barriers presented for recruitment and retention among minority participants in such studies. Also, our research partners from the AIDS Malignancy Clinical Trials (AMC) consortium will present study findings with the objective to increase awareness and willingness among health care professionals in Puerto Rico to participate in future HIV/HPV related clinical trials.

Download the announcement.

STATA: A Hands-On Introduction to Database Management and Basic Descriptive Statistics

When May 24, 2012
from 01:00 PM to 04:00 PM
Where Janer Computer Center, Graduate School of Public Health, UPR-MSC
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Instructor:    Heidi Venegas, DrPH, MS - DBE Biostatistics Leader

SPSS Hands-On Workshop

Sponsored by the Research Design, Biostatistics and Clinical Research Ethics (DBE) key function of the Puerto Rico Clinical and Translational Research Consortium (PRCTRC)
When Apr 19, 2012
from 01:00 PM to 05:00 PM
Where 4th Floor, Rm 473-A, Computer Center Medical Sciences Campus
Contact Name
Contact Phone 787-759-0306 Ext. 239
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Instructors:

  • Linnette Rodríguez, PhD, MS - Department of Biostatistics and Epidemiology, Graduate School of Public Health, UPR-MSC
  • Raúl Ramón, MS - Data Analyst and PRCTRC DBE Coordinator at Universidad Central del Caribe (UCC)

 

***Spaces are limited***
For reservations, please contact Mariely Nieves-Plaza, PRCTRC DBE Coordinator at UPR-MSC via email (mariely.nieves1@upr.edu) or by phone (787) 759-0306, extension 239. Since the training activity is a hands-on workshop, no transmission will be available to UCC and Ponce School of Medicine & Health Sciences. However, investigators from these institutions are encouraged to attend this workshop.  

Guidelines for Setting Up a Regulatory Binder

When Apr 18, 2012
from 11:00 AM to 12:00 PM
Where PRCTRC Conference Room
Contact Name
Contact Phone 787-759-0306 Ext. 228
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Speaker:
Georgamaly Estronza, MS
Medical Sciences Campus
IRB Administrator - Compliance Officer

 


This activity is sponsored by the Regulatory Knowledge and Support Key Function

2012 Grantsmanship Workshop

When Apr 02, 2012
from 08:00 AM to 04:00 PM
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The Post-doctoral Master of Science in Clinical Research, in partnership with the Multi-disciplinary Training and Career Development (MTCD) Key Function of the Puerto Rico Clinical and Translational Research Consortium (PRCTRC) are pleased to announce the schedule for the Summer 2012 schedule for the Grantsmanship Workshop.

12 sessions  starting:
June 4, 2012 – October 1, 2012

 

APPLICATION DUE DATE:  April 13, 2012

For more information download the following documents:

Integrating Principles of Science, Practice and Policy in Health Disparities Research

The conference will be transmitted to the University of Puerto Rico, Medical Sciences Campus (UPR-MSC) and Ponce School of Medicine & Health Sciences (PSM & HS) by joining Go to Meeting (gotomeeting.com).
When Mar 15, 2012
from 11:00 AM to 12:00 PM
Where Universidad Central del Caribe (UCC)
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Speaker:

Angel M. Mayor, MD, MS

Conference description:
The term health disparity describes a type of injustice that arises from unequal access to resources, such as education, health care, clean water, and clear air, resulting in an uneven disease distribution. Health disparities may be the underlying cause of several social and environmental vulnerabilities, including those that operate on individual, community, and society-wide levels. It is important to understand these disparities, so that they can be correctly identified, approached and managed. The present conference will introduce the concepts of health disparity, their causes and the paradigm shifting recommendation in research to reduce these gaps.


For additional information and space reservation at UCC please call 787-787-8710 or 787-787-8722.
For space reservation at UPR-MSC please contact Mariely Nieves at mariely.nieves1@upr.edu.
For investigators at PSM & HS, please contact Wanda Vega at wvega@psm.edu.

Ciclo de Conferencias de Investigación Traslacional en Salud de la Mujer

Primera: La Aportación de las Ciencias Básicas
When Mar 08, 2012
from 10:30 AM to 01:00 PM
Where Anfiteatro Escuela de Medicina Dental
Contact Phone 787-758-2525 ext. 1368
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Recursos:


María José Crespo, PhD
Catedrática
Departamento de Fisiología
Escuela de Medicina, RCM-UPR

Annabelle Segarra, PhD
Catedrática
Departamento de Fisiología
Escuela de Medicina, RCM-UPR

Dipak Banejee, PhD
Catedrático
Departamento de Bioquímica              
Escuela de Medicina RCM-UPR

Lynnette Ruíz,PhD
Profesora Adjunta
Escuela de Medicina
Unidad de Medicina Comparada

Delia M. Camacho,PhD
Catedrática
Escuela de Profesiones de la Salud
Directora
Centro Mujer y Salud RCM-UPR

¡Esperamos contar con su presencia!
Llamar para confirmar, espacios limitados.
787-758-2525 ext. 1368

Parcialmente subvencionado por el PRCTRC:  “National Center for Research Resources” (U54 RR 026139-01A1) y el “National Institute on Minority Health and Health Disparities” (8U54 MD 007587-03) de los Institutos Nacionales de Salud (NIH).

3rd Multidisciplinary Conference in Clinical Research & 3rd Summit of Translational Research in Health Disparities

Save the Date
When Feb 23, 2012 12:00 AM to
Feb 24, 2012 12:00 AM
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Objectives:

Disseminate successful strategies to optimize the capabilities and resources to conduct clinical and translational research.

Promote the integration of effective models to develop independent clinical and translational researchers.

Strengthen research education, training, and networking through information technology tools.

 

Call for Poster Presentation

Abstract Submission Deadline: December 14, 2011

Download the announcement.

Preliminary Scientific Program

 

 


Introduction to Qualitative Health Research

Save the Date.
When Feb 09, 2012
from 11:00 AM to 12:00 PM
Where PRCTRC Conference Room
Contact Name
Contact Phone (787) 759-0306 Ext. 234
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This short conference will provide an introduction to qualitative research
and its applications in the health field. The logistics, epistemological,
conceptual and ethical-political fundaments of qualitative research in the
study of health related problems and issues will be presented. The most
commonly used tools and methods for this field will be described. Also,
the peculiarities of qualitative versus quantitative approach in terms of
rigor and application of findings will be discussed. The discussion of
some research examples from the qualitative paradigm point of view will be
included for further understanding our research area.
Download the announcement.

Workshop: Understanding Genetic Admixture and its Implications for Complex Diseases

When Feb 09, 2012
from 08:00 AM to 04:00 PM
Where Conrado Asenjo Library 6th Flor (MSC)
Contact Name
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Registration: lizbelle.dejesus@upr.edu
Limited to 30 participants
Sponsored by: Collaborations and Partnerships / Multidisciplinary Training and Career Development

Program

Time

Activity

Speakers

8:00-8:30AM

Registration


8:30-  9:00

Genetic Markers and Variation

Dr. Rick Kittles

9:00-  9:15

Q&A


9:15 - 9:45

Human Population Variation

Dr. Rick Kittles

9:45- 10: 00

Q&A


10:00-10:30

Break


10:30-11:00

Genetic Admixture: Methodological Issues

Dr. Rick Kittles

11:00-11:15

Q&A


11:15-11:45

Genetic Admixture: practical implications in disease studies


11:45-Noon

Q&A

Dr. Margarita Irizarry Ramírez

Noon

Light lunch will be served


1:30-3:30 PM

Hands on experiences in the use of computer programs

for admixture applications and  discussion of the underlying statistical methodology.

Seminar io: “Ómicas: Proteómica y sus Posibilidades en la Investigación Clínica y Traslacional”

When Jan 20, 2012
from 10:00 AM to 10:00 AM
Where 3rd Floor - School of Nursing (Room 316)
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Speaker:

Horacio Serrano Rivera, MS, PhD
Professor, School of Public Health
& School of Medicine MSC

Limited availability.  Please confirm your attendance by email: lizbelle.dejesus@upr.edu.

Sponsored by PRCTRC - Multidisciplinary Training and Career Development
Puerto Rico Clinical and Translational Research Consortium, NCRR, NIH Grant  1U54RR026139-01

2011 PRCTRC Scientific Day

When Dec 09, 2011
from 08:00 AM to 04:00 PM
Where FOUR POINTS BY SHERATON CAGUAS REAL HOTEL & CASINO
Contact Name
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Funding

The project is supported by grant 8U54MD007587-03 (RCMI Clinical and Translational Research award, University of Puerto Rico Medical Sciences Campus) from the National Institute on Minority Health and Health Disparities (NIMHD), a component of the National Institutes of Health (NIH). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of NIMHD or NIH.

Consortium Institutions

The Puerto Rico Clinical and Translational Research Consortium is a collaborative project of the the University of Puerto Rico Medical Sciences Campus, Universidad Central del Caribe and Ponce School of Medicine and Health Sciences.