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Alcohol impairment of immune function, host defense and tissue homeostasis (R21): PA-12-026

FOA Purpose: This Funding Opportunity Announcement (FOA) invites applications from researchers with broad ranges of expertise to study the consequences of alcohol consumption on immune function with the ultimate goal of alleviating infection and reversing alcohol-induced organ damage.

Susceptibility to infection and organ damage are the two most common causes of alcohol-related morbidity and mortality. These consequences of alcohol abuse are closely associated with profound impairment of the host innate and adaptive immune systems. The mechanisms of these immune alterations and their link with alcohol-related medical problems are, in most cases, poorly understood. The goal of this FOA is to attract applications on basic and translational research: 1) to identify how alcohol alters immune function; 2) to establish functional links between immune alterations and alcohol related infections and organ damage; and 3) to develop means for mitigating immune impairment with the goal of alleviating alcohol-induced pathology.

Letter of Intent Due Date: Not applicable.

Application Due Date(s): Standard dates apply, by 5:00 PM local time of applicant organization.

Expiration Date: January 8, 2015


The project is supported by grant 8U54MD007587-03 (RCMI Clinical and Translational Research award, University of Puerto Rico Medical Sciences Campus) from the National Institute on Minority Health and Health Disparities (NIMHD), a component of the National Institutes of Health (NIH). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of NIMHD or NIH.

Consortium Institutions

The Puerto Rico Clinical and Translational Research Consortium is a collaborative project of the the University of Puerto Rico Medical Sciences Campus, Universidad Central del Caribe and Ponce School of Medicine and Health Sciences.