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Identification and Analysis of Causal Variants: Follow-Up on Genome-Wide Association Studies for Arthritis and Musculoskeletal and Skin Diseases (R21): PAR-12-230

http://grants.nih.gov/grants/guide/pa-files/PAR-12-230.html

FOA Purpose: This Funding Opportunity Announcement (FOA), issued by the National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, encourages applications that are exploratory/developmental and highly innovative in nature, and aim to characterize the genetic variations in human genomic regions that have been putatively associated with complex diseases relevant to the NIAMS mission. The purpose is to accelerate the discovery of causal genes and variants that influence the risk for disease; and conduct follow-up studies of particular genetic variants to gain novel insights into the functions of these variants and the mechanisms by which they may contribute to disease. Genomic regions of interest are primarily those identified by genome-wide association studies (GWAS) although other types of evidence may also inform the rationale for a given study. These studies are essential for the translation of initial GWAS finding into biological insights, and ultimately important for improving our understanding of the molecular mechanisms of disease that could lead to predictive, diagnostic, and therapeutic advances.

Companion Funding Opportunity:

Letter of Intent Due Date: October 20, 2012, April 20, 2013, October 20, 2013

Application Due Date(s): November 20, 2012, May 20, 2013, November 20, 2013, by 5:00 PM local time of applicant organization.

Expiration Date: November 21, 2013

 

Funding

The project is supported by grant 8U54MD007587-03 (RCMI Clinical and Translational Research award, University of Puerto Rico Medical Sciences Campus) from the National Institute on Minority Health and Health Disparities (NIMHD), a component of the National Institutes of Health (NIH). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of NIMHD or NIH.

Consortium Institutions

The Puerto Rico Clinical and Translational Research Consortium is a collaborative project of the the University of Puerto Rico Medical Sciences Campus, Universidad Central del Caribe and Ponce School of Medicine and Health Sciences.