Targeting Persistent HIV Reservoirs (TaPHIR) (R21/R33): PAR-12-109
FOA Purpose: The purpose of this FOA is to stimulate the development of innovative tools and strategies for curing HIV infection. HIV establishes latent infection in long-lived cells that form a reservoir of virus that persists in infected individuals even after years of treatment with highly active antiretroviral therapy (HAART). Curing HIV infection requires innovative strategies to identify and eliminate these reservoir cells. The task is especially difficult given the lack of HIV protein expression during latency and the low frequency of latently infected cells during treatment. Novel approaches are therefore sought to efficiently monitor and specifically target reservoirs of latently infected cells to facilitate the testing of strategies to cure HIV infection in vivo.
Letter of Intent Due Date: March 25, 2012; March 25, 2013; and March 25, 2014
Application Due Date(s): April 25, 2012; April 25, 2013, and April 25, 2014, by 5:00 PM local time of applicant organization.
Expiration Date: April 26, 2014